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PUBLICATIONS: JOURNAL MANUSCRIPTS & WHITE PAPERS

  • Sewell F, Alexander-White C, Brescia S, Currie RA, Roberts R, ROPER C, Vickers C, Westmoreland C, and Kimber I (2024). New approach methodologies (NAMs): identifying and overcoming hurdles to accelerated adoption. Toxicology Research, 13(2), tfae044. https://doi.org/10.1093/toxres/tfae044.

  • Kandárová H, ROPER C, and Dvořáková M (2024). ESTIV 2022: Key enabling non-animal technologies for research, education and testing. Toxicology in Vitro 105779. https://doi.org/10.1016/j.tiv.2024.105779.

  • Brackin T, Gayes H, Johnson I, Fox D, and ROPER C. (2024). Skin barrier function for regulatory skin absorption tests and effects on testosterone and sucrose absorption. Toxicology in Vitro 95; 105735. https://doi.org/10.1016/j.tiv.2023.105735.

  • Page K, Westerink W, Sullivan K, McDonald T, and ROPER C. (2024). Assessment of the utility of the novel Phenion® full thickness human skin model for detecting the skin irritation potential of antimicrobial cleaning products. Toxicology in Vitro 94, 105726, https://doi.org/10.1016/j.tiv.2023.105726.

  • Belsey NA, Dexter A, Vorng J-L, Tsikritsis D, Nikula CJ, Murta T, Tiddia M-V, Zhang J, Gurdak E, Trindade GF, Gilmore IS, Page L, ROPER CS, Guy RH and Boncheva Bettex M. (2023). Visualisation of drug distribution in skin using correlative optical spectroscopy and mass spectrometry imaging. Journal of Controlled Release, 364; 79-89. https://doi.org/10.1016/j.jconrel.2023.10.026.

  • ROPER CS and Neill DR. (2023). Transitioning acute in vitro inhalation toxicology testing to chronic and repeat dose testing; the challenge of mucus depletion in upper airway test systems and use of sputum mimics. Open Access Journal of Toxicology 5(4); 555669. DOI: 10.19080/OAJT.2023.05.555669.

  • Wallace J, Jackson GR, Kaluzhny Y, Ayehunie S, Lansley AB, ROPER C, and Hayden PJ. (2023). Evaluation of in vitro rat and human airway epithelial models for acute inhalation toxicity testing. Toxicological Sciences 194 (2); 178‑190. https://doi.org/10.1093/toxsci/kfad058.

  • Naik NN, Vadloori B, Poosala S, Srivastava P, Coecke S, Smith A, Akhtar A, ROPER C, Radhakrishnan S, Bhyravbhatla B, Damle M, Pulla VK, Hackethal J, Horland R, Li AP, Pati F, Singh MS, Occhetta P, Bisht R, Dandekar P, Bhagavatula K, Pajkrt D, Johnson M, Weber T, Huang J, Hysenaj L, Mallar B, Ramray B, Dixit S, Joshi S, Kulkarni M. (2023). Advances in Animal Models and Cutting-Edge Research in Alternatives: Proceedings of the Third International Conference on 3Rs Research and Progress, Vishakhapatnam, 2022. ATLA 51(4); 263-288. DOI: 10.1177/02611929231180428.

  • Turner J, Pound P, Owen C, Hutchinson I, Hop M, Chau DYS, Barrios Silva LV, Coleman M, Dubourg A, Harries LW, Hutter V, Kenna JG, Lauschke VM, Neuhaus W, ROPER C, Watkins PB, Welch J, Alvarez LR and Taylor K (2023). Incorporating new approach methodologies into regulatory nonclinical pharmaceutical safety assessment. Alternatives to Animal Experimentation. doi:10.14573/altex.2212081.

  • Kluxen FM, ROPER CS, Jensen SM and Koenig CM (2022). Characterizing local acute irritation properties of captan and folpet with new approach methods. Applied In Vitro Toxicology 8 (3); 83-101. DOI: 10.1089/aivt.2022.0004.

  • ROPER CS, Hargrove MM, Sullivan K and Wolf D (2022). Case study on the use of an Integrated Approach for Testing and Assessment (IATA) for New Approach Methodology (NAM) for refining inhalation risk assessment from point of contact toxicity of the pesticide, chlorothalonil. ENV/CBC/MONO(2022)31. OECD Environment, Health and Safety Publications Series on Testing and Assessment No. 367.  https://www.oecd.org/officialdocuments/publicdisplaydocumentpdf/?cote=env/cbc/mono(2022)31&doclanguage=en

  • Hummer J, Birngruber T, Sinner F, Page L, Toner F, ROPER CS, Moore, DJ, Baker MB and Boncheva Bettex M (2022). Optimization of topical formulations using a combination of in vitro methods to quantify the transdermal passive diffusion of drugs. International Journal of Pharmaceutics. https://doi.org/10.1016/j.ijpharm.2022.121737.

  • Welch J, Wallace J, Lansley A and ROPER C (2021). Evaluation of the toxicity of sodium dodecyl sulphate (SDS) in the MucilAir™ human airway model in vitro. Regulatory Toxicology and Pharmacology 125; 105022. https://doi.org/10.1016/j.yrtph.2021.105022.

  • Singh B, Abdelgawad ME, Ali Z, Bailey J, Budyn E, Civita P, Clift MJD, Connelly JT, Constant S, Hittinger M, Kandarova H, Kearns VR, Kiuru T, Kostrzewski T, Kress S, Durban VM, Lehr CM, McMillan H, Metz JK, Monteban V, Movia D, Neto C, Owen C, Paasonen L, Palmer KA, Pilkington GJ, Pilkington K, Prina-Mello A, ROPER C, Sheard J, Smith S, Turner JE, Roy I, Tutty MA, Velliou E, Wilkinson JM (2021). Towards more predictive, physiological and animal-free in vitro models: advances in cell and tissue Culture 2020 conference proceedings. Alternatives to Laboratory Animals 49 (3); 93-110. https://doi.org/10.1177/02611929211025006.

  • Plaza A, Toner F, Harris J, Ottersbach P, ROPER C and Mahony C (2021). Support for regulatory assessment of percutaneous absorption of retronecine-type pyrrolizidine alkaloids through human skin. Support for regulatory assessment of percutaneous absorption of retronecine-type pyrrolizidine alkaloids through human skin. Planta Medica 88 (2); 144-151. DOI 10.1055/a-1505-8524.

  • ROPER C (2019). Role of CROs in accelerating and broadening the adoption of technologies. https://www.nc3rs.org.uk/sites/default/files/documents/Organ-on-a-chip-technologies_report_FINAL.pdf

  • Clippinger AJ, Allen D, Behrsing H, BéruBé KA, Bolger MB, Casey W, DeLorme M, Gaça M, Gehen SC, Glover K, Hayden P, Hinderliter P, Hotchkiss JA, Iskandar A, Keyser B, Luettich K, Ma‑Hock L, Maione AG, Makena P, Melbourne J, Milchak L, Ng SP, Paini A, Page K, Patlewicz G, Prieto P, Raabe H, Reinke EN, ROPER C, Rose J, Sharma M, Spoo W, Thorne PS, Wilson DM and Jarabek AM (2018). Pathway‑based predictive approaches for non-animal assessment of acute inhalation toxicity. Toxicology In Vitro 52; 131–145. https://doi.org/10.1016/j.tiv.2018.06.009.

  • Rothe H, Ryan CA, Page L, Vinall J, Goebel C, Scheffler H, Toner F, ROPER C and Kern PS (2017). Application of in vitro skin penetration measurements to confirm and refine the quantitative skin sensitization risk assessment of methylisothiazolinone. Regulatory Toxicology and Pharmacology 91; 197‑207. http://dx.doi.org/10.1016/j.yrtph.2017.10.024.

  • Mitra A, Kim N, Spark D, Toner F, Craig S, ROPER C and Meyer TA (2016). Use of an in vitro human skin permeation assay to assess bioequivalence of two topical cream formulations containing butenafine hydrochloride (1%, w/w). Regulatory Toxicology and Pharmacology 82; 14‑19. http://dx.doi.org/10.1016/j.yrtph.2016.11.008.

  • Alépée N, Adriaens E, Grandidier HM, Meloni M, Nardelli L, Vinall CJ, Toner F, ROPER CS, Van Rompay AR, Leblanc V and Cotovio J (2016). Multi-laboratory evaluatation of SkinEthic HCE test method for testing serious eye damage/eye irritation using solid chemicals and overall performance of the test method with regard to solid and liquid chemicals testing. Toxicology In Vitro 34; 35-70. http://dx.doi.org/10.1016/j.tiv.2016.02.014.

  • Alépée N, Leblanc V, Adriaens E, Grandidier HM, Lelievre D, Meloni M, Nardelli L, ROPER CS, Santirocco E, Toner F, Van Rompay A, Vinall J and Cotovio J (2016). Multi-laboratory validation of SkinEthic HCE test method for testing serious eye damage/eye irritation using liquid chemicals. Toxicology In Vitro 31; 43-53. http://dx.doi.org/10.1016/j.tiv.2015.11.012.

  • Williams FM, Rothe H, Barrett G, Chiodini A, Whyte J, Cronin MTD, Monteiro-Riviere NA, Plautz J, ROPER C, Westerhout J, Yang C and Guy RH (2016). Assessing the safety of cosmetic chemicals: consideration of a flux decision tree to predict dermally delivered systemic dose for comparison with oral TTC (threshold of toxicological concern). Regulatory Toxicology and Pharmacology 76; 174-186. http://dx.doi.org/10.1016/j.yrtph.2016.01.005.

  • White EA, Horne A, Runciman J, Orazem ME, Navidi WC, ROPER CS and Bunge AL (2013). Corrigendum to “On the correlation between single-frequency impedance measurements and human skin permeability to water.”. Toxicology In Vitro 25 (2011) 2095-2104]. 
    Toxicology In Vitro 27; 993. http://dx.doi.org/10.1016/j.tiv.2012.12.008.

  • White EA, Horne A, Runciman J, Orazem ME, Navidi WC, ROPER CS and Bunge AL (2011). On the correlation between single-frequency impedance measurements and human skin permeability to water. Toxicology In Vitro 25 (8); 2095-2104. doi:10.1016/j.tiv.2011.09.011.

  • Davies M, Pendlington RU, Page L, ROPER CS, Sanders DJ, Bourner C, Pease CK and MacKay C (2011). Determining epidermal disposition kinetics for use in an integrated nonanimal approach to skin sensitization risk assessment. Toxicological Sciences 119 (2); 308–318. doi:10.1093/toxsci/kfq326.

  • Meidan VM and ROPER CS (2008). Inter- and intra-individual variability in human skin barrier function: a large scale retrospective study. Toxicology In Vitro 22; 1062–1069. doi:10.1016/j.tiv.2008.01.009.

  • Pendlington RU, Minter HJ, Stupart L, MacKay C, ROPER CS, Sanders DJ and Pease CK (2008). Development of a modified in vitro skin absorption method to study the epidermal/dermal disposition of a contact allergen in human skin. Cutaneous and Ocular Toxicology 27(4); 238-294. http://dx.doi.org/10.1080/15569520802327005

                Note: this paper was awarded a Certificate for the Best Dermatology Paper for 2008 as voted for by the Dermal Specialty                                Section of the Society of Toxicology (March 2009).

  • ROPER CS, Simpson AG, Madden S, Serex TL and Biesemeier JA (2006). Absorption of [14C]‑tetrabromodiphenyl ether (TeBDE) through human and rat skin in vitro. Drug and Chemical Toxicology 29 (3); 289-301. DOI: 10.1080/01480540600652954

  • Chilcott RP, Barai N, Beezer AE, Brain SI, Brown MB, Bunge AL, Burgess S, Cross S, Dalton CH, Dias M, Farinha A, Finnin BC, Gallagher SJ, Green DM, Gunt H, Gwyther RL, Heard CM, Jarvis C, Kamiyama F, Kasting GB, Ley EE, Lim ST, McNaughton G, Norris A, Nazemi M, Pellett MA, Quan YS, Raghavan SL, Roberts M, Rominchuck W, ROPER C, Schenk D, Simonsen L, Simpson A, Travers BD, Trottet L, Watkinson A, Wilkinson SC, Williams FM, Yamamoto A and Hadgraft J (2005). Interlaboratory variation of in vitro diffusion cell measurements: An international multi-centre study using quasi-standardised methods and materials. Journal of Pharmaceutical Sciences 94 (3); 632‑638. doi: 10.1002/jps.20229.

  • Jones AD, Dick IP, Cherrie JW, Cronin MTD, Van De Sandt JJM, Esdaile D, Iyengar S, Ten Berge W, Wilkinson SC, ROPER CS, Semple S, De Heer C and Williams FM (2004). CEFIC Workshop on methods to determine dermal permeation for human risk assessment. Research Report TM/04/07 December 2004 http://www.iom-world.org/pubs/IOM_TM0407.pdf

  • ROPER CS, Howes D, Blain PG and Williams FM (1998). A comparison of the absorption of a series of ethoxylates through rat skin in vitro. Toxicology In Vitro 12; 57‑65.

  • Lockley DJ, ROPER CS, Howes D and Williams FM (1998). Use of in vitro systems with viable skin to investigate dermal exposure to glycol ethers. Perspectives in Percutaneous Penetration, STS Publishing, Cardiff Ed Brain, James and Waters, Volume 5B; 117‑120.

  • ROPER CS, Howes D, Blain PG and Williams FM (1997). Percutaneous penetration of 2‑phenoxyethanol through rat and human skin. Food and Chemical Toxicology 35 (10-11); 1009‑1016. doi: 10.1016/s0278-6915(97)00109-9.

  • ROPER CS, Howes D, Blain PG and Williams FM (1995). Prediction of the percutaneous penetration and metabolism of dodecyl decaethoxylate in rats using in vitro models. Archives of Toxicology 69; 649‑654.​ doi: 10.1007/s002040050227.

References & Presentations: Text

PUBLICATIONS: ACKNOWLEDGEMENTS IN JOURNAL MANUSCRIPTS

  • Hargrove MM, Parr-Dobrzanski B, Li L, Constant S, Wallace J, Hinderliter P, Wolf DC and Charlton A (2021). Use of the MucilAir airway assay, a new approach methodology, for evaluating the safety and inhalation risk of agrochemicals. Applied In Vitro Toxicology 7 (2); 50-60.

  • National Academies of Sciences, Engineering, and Medicine; Division on Earth and Life Studies; Institute for Laboratory Animal Research; Rose Li and Associates, Inc.. Microphysiological Systems: Bridging Human and Animal Research: Proceedings of a Workshop—in Brief. Washington (DC): National Academies Press (US); 2021 Aug 30. PMID: 34554662.

  • Allen DG, Rooney J, Kleinstreuer N, Lowit A and Perron M (2021). Retrospective analysis of dermal absorption triple pack data. ALTEX 38(3), 463-476. doi:10.14573/altex.2101121.

  • Clippinger AJ, Raabe HA, Allen DG, Choksi N, van der Zalm A, Kleinstreuer N, Barroso J, Lowit AB (2021). Human-relevant approaches to assess eye corrosion/irritation potential of agrochemical formulations. Cutaneous and Ocular Toxicology 40(2), 145-167, DOI: 10.1080/15569527.2021.1910291.

  • Zhang Q, Flach CR, Mendelsohn R, Page L, Whitson S and Boncheva Bettex M (2020). Visualization of epidermal reservoir formation from topical diclofenac gels by Raman Spectroscopy. Journal of Pain Research 13 1621–1627.

  • Pradal J (2020). Comparison of skin permeation and putative anti-inflammatory activity of commercially available topical products containing ibuprofen and diclofenac. Journal of Pain Research 13 2805–2814.

  • Pradal J, Vallet CM, Frappin G, Bariguian F and Lombardi MS (2019). Importance of the formulation in the skin delivery of topical diclofenac: not all topical diclofenac formulations are the same. Journal of Pain Research 12 1149–1154.

References & Presentations: Text

PUBLICATIONS: ABSTRACTS AND POSTERS

  • Ejaz S, ROPER C, Finlayson Z, Saitta K, McCarthy T, Sun F and Southall M (2024). A comparative study of the in vitro dermal absorption of radiolabelled benzophenone in topical formulations through human skin. 63rd Annual Meeting and ToxExpo SOT Salt Lake City, UT, USA. Abstract and poster.

  • Dalal V, Panpatil NA, Mhaske A, Badgha R, ROPER CS and Patel M (2024). Eye hazard identification of chemicals using an in vitro method of Reconstructed Human Cornea-like Epithelium (RHCE) (OECD 492B). 63rd Annual Meeting and ToxExpo SOT Salt Lake City, UT, USA. Abstract and poster.

  • Fox D, Brackin T, Gayes H, and ROPER C (2024). Skin barrier function for regulatory skin absorption tests and effects on testosterone and sucrose absorption. 63rd Annual Meeting and ToxExpo SOT Salt Lake City, UT, USA. Abstract and poster.

  • Treasure C, Goldsby H, Conolly M, ROPER C and Ward TA (2024). Predicting acute oral toxicity using AcutoX 2: an animal product-free and metabolically relevant human cell-based test. 63rd Annual Meeting and ToxExpo SOT Salt Lake City, UT, USA. Abstract and poster.

  • ROPER C (2023). Considerations for using respiratory toxicology NAMs; lessons from OECD Case Study No. 367. Association of Inhalation Toxicologists Annual Conference 2023, Gothenburg, Sweden. Abstract and platform presentation.

  • Ward TA, Goldsby H, Connolly M, Fredson J, Jacobs F, Raza A, Suleman L, ROPER CS, and Treasure C (2023). Predicting acute oral toxicity using AcutoX 2.0: an animal product-free and metabolically relevant human cell-based test. 62nd Annual Meeting and ToxExpo SOT Nashville, TN, USA. Abstract and poster.

  • Page KE, Sullivan K, Ponder J, Gijsbrechts J, Westerink W, ROPER CS, and McDonald TA (2023). Application of a novel in vitro skin irritation test using the Phenion® FT human skin model to identify EPA Class IV skin irritant antimicrobial cleaning products. 62nd Annual Meeting and ToxExpo SOT Nashville, TN, USA. Abstract and poster.

  • Dalal V, Prajapati J, Mhaske A, Patel M and ROPER C (2023). In vitro inhalation toxicity of assay of Lambda-Cyhalothrin 5% EC Using EpiAirway™. 62nd Annual Meeting and ToxExpo SOT Nashville, TN, USA. Abstract and poster.

  • LaFollette MR, Eslami Amirabadi H, Candarlioglu P, Hobi N, ROPER C, Huang M-I, Heinz N, Miao D (2022). MPS breakthroughs in drug research & development: perspectives from commercial developers & early adopters. MPS World Summit. Abstract and poster.

  • ROPER C (2021). The terms "alternatives" and "alternatives to animals" should be confined to the history books. 10th Annual Meeting of the ASCCT. Abstract and poster. 

  • Page K, Sullivan K, Westerink W and ROPER C (2020). A novel in vitro skin irritation test designed for antimicrobial cleaning mixtures using the Phenion® FT human skin model. 59th Annual Meeting and ToxExpo SOT Anaheim, CA, USA. Abstract and poster.

  • Li Y, Wallace J, Paulo H, Rogerson P, Seddon E, ROPER C and Sweet L (2020). A new approach methodology for assessment of acute respiratory toxicity using the MucilAir™ airway model in vitro. 59th Annual Meeting and ToxExpo SOT Anaheim, CA, USA. Abstract and poster.

  • ROPER CS, Storey E, Paulo H and Wallace J (2020). Effect of Tyloxapol treatment on % active cilia, cilia beating frequency, and, mucociliary clearance in MucilAir-Cystic Fibrosis tissues. 59th Annual Meeting and ToxExpo SOT Anaheim, CA, USA. Abstract and poster.

  • Wagstaff M, Young A, ROPER C, McElroy M, Aarbiou J, and Zuurmond A (2020). Early de-risking approaches for identification of anti-fibrotics for idiopathic pulmonary fibrosis (IPF) treatment. 59th Annual Meeting and ToxExpo SOT Anaheim, CA, USA. Abstract and poster.

  • ROPER C (2019). New approach methodologies: skin absorption quantitative risk assessment and respiratory toxicology. New approach methodology use for regulatory application; integrated approaches to testing and assessment, Houston, TX, USA. Abstract https://www.eiseverywhere.com/website/6947/agenda/.

  • ROPER CS, Baily JE, Simpson HJ and Vinall JL (2019). Assessment of alveolar toxicity and fibrotic potential in vitro using the MatTek EpiAlveolar™ model. 58th Annual Meeting and ToxExpo SOT Baltimore, MD, USA. Abstract and poster.

  • Vinall J, Simpson H, Baily J and ROPER C (2018). Comparison of histopathological and cell viability results from in vitro rat and human airway™ models for translational inhalation toxicity testing. Association of Inhalation Toxicologists, Durham, NC, USA. Abstract and poster.

  • Simpson H, Hayden P, Jackson GJ, Vinall J, Storey E, Debatis M, Maione A, ROPER C and Klausner M (2018). Evaluation of in vitro models of the rat and human airway epithelium for assessment of acute toxicity. EUSAAT, Linz, Austria. Abstract and poster.

  • Simpson H, Baily J, ROPER C and Vinall J (2018). Evaluation and comparison of in vitro rat and human airway epithelial models for inhalation toxicity testing. LIVE, Nice, France. Abstract and poster.

  • Learn DB, ROPER CS, Craig S and Toner F (2018). An assessment of the intra-lab variability of the in vitro percutaneous absorption of testosterone through human skin. 57th Annual Meeting and ToxExpo SOT San Antonio, TX, USA. Abstract and poster.

  • ROPER CS, Vinall J and Welch J (2018). Evaluation of the toxicity of sodium dodecyl sulfate (SDS) in the MucilAir™ human airway model in vitro. 57th Annual Meeting and ToxExpo SOT San Antonio, TX, USA. Abstract and poster.

  • Hayden PJ, Jackson GR, Vinall JL, Storey E, Simpson H, Debatis M, Maione AG, ROPER CS, Klausner M. Comparison of in vitro rat and human airway epithelial models for inhalation toxicity testing. 57th Annual Meeting and ToxExpo SOT San Antonio, TX, USA. Abstract and poster.

  • Page L, McArthur C, Toner F and ROPER CS (2017). Phenyl acetate esterase and MTT reduction as markers for enzyme stability in human skin discs in vitro. Skin Metabolism Meeting (SMM3), Sunderland, UK. Abstract and poster.

  • ROPER CS, Craig S and Toner F (2017). Evaluation of the effect of occlusion on the absorption of the reference test item, [14C]-Testosterone, applied to human skin in vitro. Society of Toxicology, 56th Annual Meeting, Baltimore, MD, USA. Abstract and poster.

  • ROPER CS, Vinall JL, Welch JB, Paulussen JJC, Rijk JCW and Westerink WMA (2017). Skin sensitisation testing strategy and in-house fit-for-purpose validations at Charles River Laboratories. Society of Toxicology, 56th Annual Meeting, Baltimore, MD, USA. Abstract and poster.

  • Vinall JL, ROPER CS, Paulussen JJC, Rijk JCW, Westerink WMA and Welch JB (2016). Skin sensitisation testing strategy and in-house fit-for-purpose validations at Charles River. In Vitro Toxicology Society, Glasgow, UK. Poster.

  • ROPER CS, Vinall JL and Welch J (2016). Ocular irritation risk assessments using in vitro BCOP (OECD 437) and 3D assays (OECD 492). Society of Toxicology, 55th Annual Meeting, New Orleans, LA, USA. Abstract and poster.

  • Williams FM, Chiodini A, Barrett G, Cronin MTD, Guy RH, Plautz J, Monteiro-Riviere NA, ROPER C, Rothe H, Rua D, Westerhout J
    and Yang C (2016). Findings of a Task Force for extending use of Threshold of Toxicological Concern (TTC): a strategy to support application of TTC to dermally applied cosmetic ingredients. Society of Toxicology, 55th Annual Meeting, New Orleans, LA, USA. Abstract and poster.

  • Leblanc V, Adriaens E, Grandidier MH, Hollanders K, Jacobs A, Meloni M, Nardelli L, ROPER C, Santiocco E, Toner F, Van Rompay A, Vinall J, Cotovio J and Alépée N (2016). Prospective multicentric study of reconstructed human corneal SkinEthic HCE test method for serious eye damage/eye irritation testing. Society of Toxicology, 55th Annual Meeting, New Orleans, LA, USA. Abstract and poster.

  • Leblanc V, Adriaens E, Grandidier MH, Hollanders K, Jacobs A, Meloni M, Nardelli L, ROPER C, Santiocco E, Toner F, Van Rompay A, Vinall J, Cotovio J and Alépée N (2016). Intra- and inter-laboratory evaluation of SkinEthic™ HCE test method on solid and liquid chemicals for serious eye damage / eye irritation assessment. Society of Toxicology, 55th Annual Meeting, New Orleans, LA, USA. Abstract and poster.

  • Vinall JL, Roper CS, Welch JB (2015). Ocular irritation risk assessment in vitro using BCOP (OECD 437) and 3D Assays (OECD 492). IVTS, Birmingham, UK. Poster.

  • Vinall J, Simpson H, Toner F, Welch J and ROPER C (2015). In house validation of the bovine corneal opacity and permeability assay and EpiOcular™ eye irritation test. EUSAAT, Linz, Austria. Poster.

  • Toner F, Swanson A, Welch J and ROPER CS (2014). Validation of direct peptide reactivity assay (DPRA) for fifteen reference chemicals for prediction of skin sensitisation. Skin Forum, Prague, Czech Republic. Abstract and poster.

  • ROPER CS, Murray DA, Welch J, and Madden S (2014). Developing regulatory acceptable in vitro methods. Abstracts of the World Congress, Prague, Czech Republic.  ALTEX Proceedings 3(1) 289, iv‑5‑691. Abstract and poster.

  • Williams FM, Ambrosio M, Barrett G, Cronin MTD, Guy RH, Monteiro-Riviere NA, Plautz J, ROPER C, Rothe H, Rua D, Westerhout J and Yang C (2014). Findings of a Task Force for extending use of threshold of toxicological concern (TTC): A strategy to support application of TTC to dermally applied cosmetic ingredients. 14th International Conference. Perspectives in Percutaneous Penetration, La Grande Motte, France. Abstract Book, Volume 14, p 112. Abstract and poster.

  • Williama FM, Barrett G, Chiodini A, Cronin MTD, Guy RH, Plautz J, Monteiro-Riviere NA, ROPER C, Rothe H, Rua D, Westerhout J and Yang C (2014). Threshold of toxicological concern (TTC); a strategy to support application of TTC to dermally applied cosmetic ingredients. Society of Toxicology, 53rd Annual Meeting, Phoenix, AZ, USA. Abstract and poster.

  • Bain C and ROPER C (2014). Validation of Litron MicroFlow® in vitro micronucleus test. EEMS. Lancaster, UK. Poster.

  • Welch J and ROPER CS (2013). Evaluation of EpiOcular™ EIT for assessment of ocular irritation potential in vitro. IVTS, Leicester, UK. Abstract and poster.

  • Welch J, Barkby CT and ROPER CS (2013). Assessment of skin metabolic capacity in vitro: luciferin assays. 2nd Skin Metabolism Meeting, Valbonne, France. Abstract and poster.

  • Page L, Toner F and ROPER C (2013). Effect of receptor fluid and area on testosterone absorption across human skin. Skin Forum, London, UK. Abstract and poster.

  • Welch J, Dickie A and ROPER C (2012). An evaluation of in silico modelling for endpoints of toxicological relevance. IVTS, London, UK. Abstract and poster.

  • Toner F and ROPER C (2012). [14C]‑Testosterone: a marker assay for human skin absorption. Stratum Corneum/ Skin Forum, Cardiff, UK. Abstract and poster.

  • Dickie A, Dowers K, ROPER CS and Welch J (2012). An optimised Mucin ELLA assay for MucilAir™. SULSA, Edinburgh, UK. Abstract and poster.

  • Dickie A, ROPER CS, Constant S, Huang S and Welch J (2012). MucilAir™: a new human airway model, evaluated for use in toxicity studies. SULSA, Edinburgh, UK. Abstract and poster.

  • Blackstock C, Toner F, Horne A and ROPER C (2012). Evaluation of electrical resistance for use as a rapid method for human skin barrier integrity assessment in the flow-through diffusion cell. PPP, La Grande Motte, France. Abstract and poster.

  • Dickie AR, ROPER CS, Constant S, Huang S and Welch J (2012). MucilAir™, an in vitro model for assessment of human airway toxicity, evaluated using model irritant sodium dodecyl sulphate (SDS). British Toxicology Society Annual Congress, Warwick, UK. Abstract and poster.

  • Welch J, Dickie A and ROPER CS (2011). Evaluation of MucilAir™ for toxicity testing in vitro. IVTS, Liverpool, UK. Abstract and poster.

  • Madden S and ROPER C (2011). Developing regulatory acceptable in vitro alternatives to established in vivo assays. WC8, Montreal, Canada. Poster.

  • Runciman J, Page L, Toner F and ROPER C (2011). Evaluation of a rapid tritiated water barrier integrity test for rat skin. Skin Forum, Frankfurt, Germany. Poster.

  • ROPER CS, Patterson A and Toner F (2011). An in vitro model for determination of human ungual and transungual drug delivery. Nail Forum, London, UK. Abstract.

  • Welch J, Murie E, McMillan C, Bain C, Cahill P, Hughes C, ROPER C and Madden S (2010). Evaluation of BlueScreen HC and HC S9 assays for genetic toxicity screening. IVTS, Liverpool, UK. Abstract and poster.

  • Welch J, McMillan C, ROPER C and Madden S (2010). Evaluation of SkinEthic® HCE for assessment of ocular irritation potential. IVTS, Liverpool, UK. Abstract and poster.

  • Wilkinson S and ROPER C (2010). Inter-laboratory comparison of the penetration of caffeine through silicone membranes in vitro. Skin Forum, Edinburgh, UK. Abstract and poster.

  • Blackstock C and ROPER CS (2010). Assessment of the effects of pre-incubation time on irritation potential using the EpiSkin® in vitro irritation test. Skin Forum, Edinburgh, UK. Abstract and poster.

  • Toner F, ROPER CS and Prowse G (2010). The in vitro assessment of different methods for removal of radiolabelled biocide in a solvent-based paint formulation from human skin. Skin Forum, Edinburgh, UK. Abstract and poster.

  • ROPER C, Toner F, Page L, Rothe H and Scheffler H (2010). Representative exposure scenario of shampoo and conditioning treatment for hair care stylists; absorption of [14C]‑methylisothiazilinone through human skin in vitro. Perspectives in Percutaneous Penetration, La Grande Motte, France. Abstract and poster.

  • Davies M, Pendlington RU, Minter HJ, Page L, ROPER CS, Sanders DJ, Bourner C, Pease CK and MacKay C (2009). Determination of epidermal bioavailability of sensitizing chemicals from time course skin absorption experiments and multi-compartmental modelling. OEESC 2009, Edinburgh, UK. Abstract and platform presentation by Dr Davies.

  • Runciman J, ROPER C and Madden S (2009). Evaluation of a rapid tritiated water skin barrier integrity method for use in regulatory toxicology testing in vitro. OEESC, Edinburgh, UK. Abstract and poster.

  • Toner F, Garcia B, ROPER C and Madden S (2009). Effect of repeat application of [14C]‑Caffeine on percutaneous absorption through human skin in vitro. OEESC, Edinburgh, UK. Abstract and poster.

  • Meidan VM and ROPER CS (2009). The variability of human skin barrier: an analysis of 2400 samples obtained from 112 donors. OEESC, Edinburgh, UK. Abstract and poster.

  • ROPER CS, Madden S and Marsh S (2008). Assessment of the barrier function of cow skin membranes in vitro. Skin Forum, University of London, UK. Abstract and poster.

  • ROPER CS, Neil M, Madden S and Guenther C (2008). Penetration of [14C]‑Ciclopirox in two formulations through human nail in vitro. Skin Forum, University of London, UK. Abstract and poster.

  • Pendlington RU, Minter HJ, Stupart L, MacKay C, ROPER CS, Sanders DJ, and Pease CK (2008). Development of a modified in vitro skin absorption method to study the epidermal/ dermal disposition of a contact allergen in human skin. ESA Salzburg, Austria. Abstract and poster.

  • Madden S, ROPER C, Biesemeier J, McBriarty J and Rothenbacher K (2007). Toxicological risk assessment using in vitro dermal models: importance of washing procedures. ISSX 2007, Sendai, Japan. Abstract and poster.

  • Pendlington RU, Minter HJ, Stupart L, MacKay C, ROPER CS, Sanders DJ, and Pease CK (2007). Development of a modified in vitro skin absorption method to study the epidermal/dermal disposition of a contact allergen in human skin. Occupational and Environmental Exposures of Skin to Chemicals 17-20 June 2007, Golden, Colorado, USA. Abstract and poster.

  • Pendlington RU, Minter HJ, Stupart L, MacKay C, ROPER CS, Sanders DJ, and Pease CK (2007). Further development of an in vitro skin absorption method to measure compartmental disposition and kinetics for chemicals in skin. Toxicology Letters, Vol. 172, Supl 1, S106.

  • ROPER CS, Toner F, Prowse G, Hunter J and Madden S (2006). The in vitro percutaneous absorption of radiolabelled biocide in a single solvent-based paint formulation through human skin. Skin Forum, Sheffield, UK. Abstract and poster.

  • Toner F, ROPER CS and Madden S (2006). The in vitro absorption of radiolabelled caffeine, benzoic acid and testosterone through human skin. Perspectives in Percutaneous Penetration 2006 Conference, La Grande Motte, France. Abstract and poster.

  • Toner F, ROPER C and Madden S (2006). Maintenance of human skin barrier function for 1 week in an in vitro test system. ISSX, Puerto Rico. Abstract and poster.

  • Jones AD, Dick IP, Cherrie JW, Cronin MTD, Van De Sandt JJM, Esdaile D, Iyengar S, Ten Berge W, Wilkinson SC, ROPER CS,
    Semple S, De Heer C and Williams FM (2005). Recommendations from the CEFIC International workshop on methods to determine dermal permeation for human risk assessment. OEESC, Sweden. Abstract and poster.

  • Madden S, ROPER CS and Greenough RJ (2004). In vitro assessment of styrene absorption through human skin. SOT, Baltimore, USA. Abstract and poster.

  • ROPER CS, Crow LF and Madden S (2004). Should we use a barrier integrity test for skin barrier function of human skin in skin penetration studies? Perspectives in Percutaneous Penetration 2004 Conference, La Grande Motte, France. Poster.

  • Madden S, ROPER C, Phillips M, Serex T and Biesemeier J. (2003). Absorption of [14C]‑tetrabromodiphenyl oxide (TBDPO) through rat and human skin in vitro. Drug Metabolism Reviews 35, Supplement 2, 448P.  Presented at 12th North American ISSX Meeting, Providence, RI, USA.

  • Madden S, ROPER C and Phillips M (2003). Skin absorption of xenobiotics in vitro. Drug Metabolism Reviews 35, Supplement 2, 58P. Presented at 12th North American ISSX, Meeting, Providence, RI, USA.

  • ROPER CS, Simpson AG, Madden S and Cameron BD (2000). Tritiated water permeability coefficient assessment and rejection criteria for barrier function of human skin. In: Brain KR, Walters KA (Eds.), Perspectives in Percutaneous Penetration, Vol. 7A. STS Publishing, Cardiff, p. 48. Poster presented at the Perspectives in Percutaneous Penetration 2000 Conference, La Grande Motte, France.

  • Fasano WJ and ROPER CS (2000). Comparative in vitro dermal absorption kinetics of a water soluble agrochemical through human, rat and rabbit skin. Perspectives in Percutaneous Penetration 7A, 120. Poster presented at the Perspectives in Percutaneous Penetration 2000 Conference, La Grande Motte, France. Poster.

  • McColl C, Madden S, Gentile DM, Cheung Y-L, Simpson A, ROPER CS and Dougal L (2000). Investigation of hepatic CYP activities in sheep and chicken. Drug Metabolism Reviews 32, Supplement 1; 78. Poster at DMW/ISSX Joint Meeting, St Andrews, Scotland. Abstract and poster.

  • Simpson AG, ROPER CS and Cameron BD (1998). Comparison of tritiated water penetration coefficients as predictors for human skin barrier integrity. In: Brain, K.R., Walters, K.A. (Eds.). Perspectives in Percutaneous Penetration, Vol. 6A. STS Publishing, Cardiff, p. 61. Poster presented at the Perspectives in Percutaneous Penetration ‘98 Conference, Leiden, The Netherlands.

  • Lockley DJ, ROPER CS, Howes D and Williams FM (1998). Use of in vitro systems with viable skin to investigate dermal exposure to glycol ethers. Perspectives in Percutaneous Penetration 5A; 53.

  • ROPER CS, Bal W and Mathers JC (1996). Dose-response effects of dietary carrageenan (from Eucheuma cottonii) on blood lipids and gut tissues of rats. Proceedings of the Nutrition Society 55 (1A); 55A. Abstract.

  • ROPER CS, Bal W and Mathers JC (1996). Comparison of two algal polysaccharides with guar gum and cellulose on bowel habit in healthy human volunteers. Proceedings of the Nutrition Society 55 (3); 238A. Abstract.

  • ROPER CS, Bal W and Mathers JC (1995). Dose-response effects of dietary carrageenan (from Eucheuma cottonii) on blood lipids and gut tissues of rats. Nutrition Society Summer Meeting, University of Aberdeen, 11-14 July 1995. Poster

  • ROPER CS, Howes D, Blain PG and Williams FM (1994). Prediction of percutaneous absorption using in vitro methods. UK and S&N Drug Metabolism Group Meeting, Unilever Research, Sharnbrook, Bedfordshire, UK, 22 June 1994. Poster.

  • ROPER CS, Howes D, Blain PG and Williams FM (1993). Absorption and metabolism of 2‑phenoxyethanol through rat and human skin in vitro. Human and Experimental Toxicology 12 (5); 427.

  • ROPER CS, Howes D, Blain PG and Williams FM (1993). Absorption of dodecyl decaethoxylate through rat skin in vitro. Pharmacology and Toxicology 73; Supplement II, Abstract Volume p36.

  • Williams FM, Clark NWE, ROPER CS, Dick IP and Blain PG (1993). Absorption and metabolism through rat skin in the flow through diffusion cell. The Toxicologist 13 (1); 51.

  • ROPER CS, Howes D, Blain PG and Williams FM (1993). Percutaneous absorption of dodecyl monoethoxylate across rat skin in vitro and in vivo. Human and Experimental Toxicology 13 (4); 294.

  • ROPER CS, Howes D, Blain PG and Williams FM (1993). Percutaneous absorption of dodecyl monoethoxylate across rat skin in vitro and in vivo. British Toxicology Society Autumn Meeting. University of York, 22-24 September 1993. Poster.

  • ROPER CS, Howes D, Blain PG and Williams FM (1992). The absorption and metabolism of 2-phenoxyethanol through rat and human skin in vitro. British Toxicology Society Autumn Meeting. University of Wales, Cardiff, 21-23 September 1992. Poster.

  • Seal CJ, ROPER CS and Parker DS (1991). Effect of intraruminal propionate infusion on rumen fermentation and whole body glucose turnover rate in forage-fed steers. Proceedings of the Nutrition Society 50 (1); 78A.

References & Presentations: Text

PLATFORM PRESENTATIONS, BLOGS, WEBINARS AND PODCASTS

  • Hsiao W-K and ROPER C (2024). Precise sample collection at the drug target site of action using open flow microperfusion (OFM). Exhibitor Session with BASi Research Products and Joanneum Research. 63rd Annual Meeting and ToxExpo SOT Salt Lake City, UT, USA. 13 March 2024.

  • Deshpande A and ROPER C (2024). Can NAMs become the testing strategy of choice by 2035? CRO and industry perspectives. Exhibitor Session with JRF Global. 63rd Annual Meeting and ToxExpo SOT Salt Lake City, UT, USA. 12 March 2024.

  • ROPER C (2024). Non-animal methods for acute inhalation toxicity. AM05: Nix the Six: strategies for implementing nonanimal acute toxicity testing. Continuing Education Course. 63rd Annual Meeting and ToxExpo SOT Salt Lake City, UT, USA. 10 March 2024.

  • ROPER C (2024). Standardization and validation of complex in vitro models. Organ Chip Master Class, London, UK. 09 March 2024.

  • ROPER C (2024). Why do we fail to replace animal models with scientifically rational non-animal models? Organ Chip Master Class, London, UK. 09 March 2024.

  • ROPER C (2024). In vitro respiratory toxicology; a strategic overview of developments and advancements in 3D models and methods with case studies from industry. 3D Cell Culture Workshop and Conference, Mumbai, India. 02 February 2024.

  • ROPER C (2024). Standardization and validation of complex in vitro models. Organ Chip Master Class, 3D Cell Culture Workshop and Conference, ICT, Mumbai, India. 29 January 2024.

  • ROPER C (2024). Why do we fail to replace animal models with scientifically rational non-animal models? Organ Chip Master Class, 3D Cell Culture Workshop and Conference, ICT, Mumbai, India. 29 January 2024.

  • ROPER C (2023). Reintroducing the 3Rs and perspectives from working with regulators. 12th Annual Tumour Models, London, UK. Lecture. 06 December 2023.

  • ROPER C (2023). Respiratory Toxicology Services. The 3Rs Collaborative Lung Workshop. Webinar Lecture. 17 October 2023.

  • ROPER C (2023). Considerations for using respiratory toxicology NAMs; lessons from OECD Case Study No. 367. Association of Inhalation Toxicologists, Gothenburg, Sweden. Lecture. 03 May 2023.

  • ROPER C (2023). Considerations for using respiratory toxicology NAMs; lessons from OECD Case Study No. 367. Invitrolize, Luxembourg Institute of Science and Technology. Luxembourg. Lecture. 27 Apr 2023.

  • ROPER C (2022). Why do we fail to replace animal models with scientifically rational non-animal models? Advances in Animal Models and Cutting-Edge Research in Alternatives, Vishakhaptnam, AP, India, 17-18 November 2022. https://www.3radvances.com.

  • ROPER C (2022). An introduction to new approach methods, on a chip technologies and expectations of the FDA Modernization Act. Roundtable of Toxicology Consultants, webinar. 18 October 2022.

  • ROPER C (2022). Why do we fail to replace animal models with scientifically rational non-animal models? What is fit for purpose and validation? Why is there no single definition of validation? Organ on a Chip MasterClass for Biomedical Scientists, Utrecht, The Netherlands, remote lecture, 05 July 2022

  • ROPER C (2022). Dermal absorption and toxicology in vitro; what are the tests, how can we use them and where are the innovations? Dermal Toxicology Specialty Section of the Society of Toxicology, webinar, 01 February 2022.

  • ROPER C (2021). Replacement in respiratory toxicology. University of Strathclyde 3Rs Seminar, virtual, 18 November 2021.

  • ROPER C (2021). Mentor Workshop 1. Respiratory toxicology using new approach methods. ACTC Virtual Conference 03 November 2021. https://theactc.com

  • ROPER C (2021). Opportunities & challenges for in vitro toxicology resulting from the US EPA announcement to be animal free by 2035. ToxGurulkul Foundation Webinar Series.

  • ROPER C, Wolf D, Hargrove MM and Sullivan K  (2021). A case study using a new approach methodology (NAM) for refining inhalation risk assessment from point of contact toxicity of the pesticide, chlorothalonil. Virtual meeting. OECD, Paris, France. 

  • ROPER C (2021). Why do we fail to replace animal models with scientifically rational non animal models? ACTC Virtual Conference 30 June 2021. https://theactc.com

  • ROPER C (2021). The use and applications of 3D tissue models for respiratory toxicology and efficacy testing within the CRO industry. https://www.nationalacademies.org/event/01-19-2021/microphysiological-systems-bridging-human-and-animal-research-a-workshop.

  • ROPER C (2021). In vitro toxicology: 3D models. Charles River internal 3D Summit.

  • McElroy M and ROPER C (2020). What's Hot in 2021: 3D Models and Nanovectors. https://www.criver.com/eureka/whats-hot-2021-3d-models-and-nanovectors.

  • Freke M, Reed M, Jarabek A, Krieger S, Randazzo J and ROPER C (2020). An integrated respiratory toxicology testing strategy amidst regulatory changes: are we ready for full replacement? Charles River Exhibitor Session with Guests. 59th Annual Meeting and ToxExpo SOT Anaheim, CA, USA. H.asp#card1d.

  • ROPER C (2019). New approach methodologies: skin absorption quantitative risk assessment and respiratory toxicology.
    Presentation at New Approach Methodology use for Regulatory Application (NURA) integrated approaches to testing and assessment, Houston, TX, USA (Skype lecture). https://www.eiseverywhere.com/website/6947/agenda/.

  • ROPER C (2019). What are New Approach Methodologies (NAMs)? Presentation to Canadian PMRA at Charles River, Montreal (Skype lecture).

  • ROPER C (2019). Current EPA activities: respiratory toxicology, dermal triple pack and replacement of the in vivo acute 6 pack with the in vitro acute 5 pack. Invited speaker at NC3Rs “NC3Rs Agrochemicals Steering Group”, London, England, UK.

  • ROPER C (2019). In vitro respiratory toxicology: study design & quality considerations. Invited speaker at US EPA, Crystal City, VA, USA.

  • ROPER C (2019). In vitro dermal skin penetration: study design & quality considerations. Invited speaker at US EPA, Crystal City, VA, USA.

  • ROPER C and Toner F (2019). Triple pack: dermal skin studies for human health risk assessment. Webinar for US EPA, Canada PMRA and California DPR organised by PCRM.

  • Gaskin P, ROPER C and Horton N (2019). How predictive toxicology is influencing regulatory approaches. https://eureka.criver.com/how-predictive-toxicology-is-influencing-regulatory-approaches/.

  • Parker M (2019). Quoted in “Can big data replace animal models?" https://eureka.criver.com/can-big-data-replace-animal-models/.

  • ROPER C (2019). Change from animal to non-animal models within regulatory toxicology: dermal absorption and respiratory toxicology. Invited lecture at the Health Innovation and Technologies Research Festival, Heriot Watt University, Riccarton, Edinburgh, UK.

  • ROPER C (2019). Inhalation toxicology: in vitro models for screening, translation and dose range finding. Lecture to students and seminar, Heriot Watt University, Riccarton, Edinburgh, UK.

  • ROPER C, Black L and Brown P (2018). In vitro and alternative models for regulatory submission. American College of Toxicology “ToxChats” podcast featuring Charles River & US FDA. https://podtail.com/podcast/toxchats/in-vitro-and-alternative-models-for-regulatory-s-2/

  • ROPER C (2018). Supporting inhalation toxicology programmes with in vitro models: screening, translation and dose range finding. Platform presentation at the Association of Inhalation Toxicologists, Durham, NC, USA.

  • Jarabek A, ROPER C and Hotchkiss J (2018). Implementing alternative approaches for inhalation toxicity testing: recent success and remaining hurdles. Platform presentation at the Association of Inhalation Toxicologists, Durham, NC, USA with EPA (AJ) and Dow (JH).

  • ROPER C (2018). Calculation of human equivalent concentrations from in vitro point of departure derived from in vitro 3D test systems. Platform presentation at the Occupational Toxicology Roundtable, Milwaukee, WI, USA.

  • ROPER C (2018). Gaining access to large quantities of standardized animal testing data: considerations, challenges and are these truly insurmountable barriers? SACATM, ICCVAM, NIH, Durham, NC, USA.

  • ROPER C (2018). The role of CROs in accelerating and broadening adoption of organ-on-a-chip technologies. Organ on a chip technologies: current status and translatability of data. NC3Rs, MRC Centre for Drug Safety and Catapult Medicines Discovery, Liverpool, UK.

  • ROPER C (2018). Waiting to inhale. http://eureka.criver.com/waiting-to-inhale/.

  • ROPER CS, Cardoso R and Hendricks G (2018). Platform presentation entitled – Where does in vitro toxicology need help? Exhibitor Session - What can in vitro toxicology learn from genetic toxicology for regulatory acceptance? Society of Toxicology, 57th Annual Meeting, San Antonio, TX, USA.

  • ROPER C, Toner F and Madden S (2019). Triple pack: dermal skin studies for human health risk assessment. Webinar for US EPA and Canada PMRA.

  • Poeltl G and ROPER C (2018). Passing the chemical sniff test. http://eureka.criver.com/passing-the-chemical-sniff-test/.

  • ROPER C (2017). Introductory lecture: A history and a peer into the future of dermal metabolism. Skin Metabolism Meeting (SMM3), Sunderland, UK.

  • ROPER CS, Rijk JCW, Stankowski L, Casey W and Learn D (2017). Platform presentation entitled - The $6 million question “Do we validate against human or animal data?”. Exhibitor Session - Trends, trials and triumphs in in vitro toxicology.
    Society of Toxicology, 56th Annual Meeting, Baltimore, MD, USA.

  • ROPER CS, Burden N and Learn D (2016). Platform presentation entitled - In vitro toxicology and integrated toxicology – what are these? Exhibitor Session – What is in vitro toxicology? Society of Toxicology, 56th Annual Meeting, Baltimore, MD, USA.

  • McEnery R (2016). ROPER C interviewed in “In vitro's growing space in safety testing”. http://eureka.criver.com/in-vitros-growing-space-in-safety-testing/.

  • McEnery R (2016). ROPER C quoted in “Animal welfare and animal viruses”. http://eureka.criver.com/animal-welfare-and-animal-viruses/.

  • ROPER CS (2015). Challenges for dermal absorption: available assays and methodologies. Cosmetics Europe LRSS Meeting, Brussels, 02-03 June 2015.

  • ROPER CS (2015). Transdermal delivery: in vitro models/ methods overview, gaps and needs. Cosmetics Europe LRSS Meeting, Brussels, 11 May 2015.

  • McElroy M, Fletcher L and ROPER CS (2015). A perfect marriage; can synthetic biology revolutionize the field of stem cell therapy?”
    Charles River Eureka Blog.

  • ROPER CS (2014). In vitro skin penetration: an overview and questions of skin biology and interpretation of data. 92nd Scottish Skin Biology Club, University of Edinburgh, UK.

  • McElroy M and ROPER CS (2013). Reducing use of animals in drug testing. Invited joint lecture. Centre for Synthetic and Systems Biology, University of Edinburgh, Edinburgh, UK.

  • ROPER CS (2012). The third dimension to animal replacement: industry needs. The Third Dimension to Animal Replacement Meeting, BBSRC/NC3Rs Tissue Engineering, London, UK.

  • ROPER CS, Patterson A and Toner F (2011). An in vitro model for determination of human ungual and transungual drug delivery. Nail Forum, London, UK.

  • ROPER C (2010). Skin penetration method in short term tests for REACh: OECD Test Guideline No. 428. IVTS, Liverpool, UK.

  • Runciman J, ROPER C and Madden S (2009). Evaluation of a rapid tritiated water skin barrier integrity method for use in regulatory toxicology testing in vitro. OEESC, Edinburgh, UK.

  • ROPER CS and Wilkinson S (2008). Interlaboratory comparison of the penetration of caffeine through silicone membranes in vitro. Skin Forum, University of London, UK.

  • ROPER CS (2008). Approaches to topical drug delivery and dermal risk assessment. 4th Charles River Autumn Seminar: Special Routes of Drug Delivery. Senri Life Sciences Centre, Osaka, Japan, 25 November 2008 and New Hall, British Embassy, Tokyo, Japan, 28 November 2008.

  • ROPER CS (2005). Barrier integrity testing using tritiated water. In Vitro Percutaneous Absorption Expert Users Workshop, IIVS, Gaithersburg, MD, USA, 20-21 July 2005. Reported in: Raabe H, Curren R, Ward S, Harbell J (2005). Report from an in vitro dermal absorption assay workshop. Presented at the 5th World Congress on Alternatives and Animal Use in Life Sciences, Berlin, Germany, 21‑25 August 2005. In vitro percutaneous absorption Expert Users Workshop 20 and 21 July 2005, Gaithersburg Hilton, Gaithersburg, USA. http://www.iivs.org/documents/116.pdf.

  • ROPER CS (2005). CEFIC Workshop on methods to determine dermal permeation for human risk assessment. 6th Annual Meeting of the Skin Forum, 29 June to 01 July 2005, University College, Winchester, UK.

  • ROPER CS (2004). CEFIC Workshop on methods to determine dermal permeation for human risk assessment.
    Utrecht, 13-15 July 2004. http://www.iom-world.org/news/ppworkshop.php.

  • ROPER CS (2004). Should we use a barrier integrity test for skin barrier function of human skin penetration studies? Perspectives in Percutaneous Penetration 2004 Conference, La Grande Motte, France.

  • ROPER CS (2001). Modelling the dermal absorption kinetics of topical drugs. Expert invited speaker at a two day seminar meeting held by Schering AG, Berlin, Germany, July 2001.

  • ROPER CS (2000). The flow through diffusion cell: a model for skin penetration in vitro. Scottish Skin Biology Club Meeting, 16 November 2000 at Inveresk Research, Tranent, Scotland.

  • ROPER CS, Bal W and Mathers JC (1996). Comparison of two algal polysaccharides with guar gum and cellulose on bowel habit in healthy human volunteers. Symposium: The nutritional consequences of complex carbohydrates. University of Dundee, 2-3 April 1996.

  • ROPER CS, Bal W and Mathers JC (1995). In vivo fatty acid and cholesterol synthesis in rats fed algal polysaccharides. EC AIR Co-ordination Meeting. MRC Dunn Unit of Clinical Nutrition, Cambridge, 25‑26 September 1995.

  • ROPER CS, Bal W and Mathers JC (1995). Responses in gastrointestinal transit time to consumption of algal polysaccharides in rats. EC AIR Co-ordination Meeting. MRC Dunn Unit of Clinical Nutrition, Cambridge, 25‑26 September 1995.

  • ROPER CS, Bal W and Mathers JC (1995). Effect of algal polysaccharides on blood lipid concentrations in healthy human volunteers. EC AIR Co-ordination Meeting, INRA, Jouy-en Josas, Paris, France, 30‑31 March 1995.

  • ROPER CS, Bal W and Mathers JC (1995). Physiological responses to algal polysaccharides in rats (a) blood lipids and (b) gut compartments. EC AIR Co-ordination Meeting, INRA, Jouy-en Josas, Paris, France, 30‑31 March 1995.

  • ROPER CS, Howes D, Blain PG and Williams FM (1994). Prediction of percutaneous absorption using in vitro methods. Unilever Environmental Safety Laboratory research seminar programme, Unilever Research, Colworth House, Sharnbrook, Bedfordshire, UK, 07 September 1994.

  • ROPER CS, Howes D, Blain PG and Williams FM (1993). The absorption of dodecyl decaethoxylate through rat skin in vitro. Eurotox '93, University of Uppsala, Sweden, 30 June‑3 July 1993.

  • ROPER CS, Howes D, Blain PG and Williams FM (1991). Metabolism of 2‑phenoxyethanol in skin. Unilever Symposium: Research into Alternatives to Animals. Unilever Research, Sharnbrook, Bedfordshire, UK, September 1991.

References & Presentations: Text
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